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:: Volume 13, Issue 2 ((پياپي 42)، زمستان 1390) ::
Koomesh 1390, 13(2): 172-176 Back to browse issues page
Association of the insulin gene polymorphism and colorectal cancer
Maral ارکانی , Akram صفائی , Khatoon کریمی , Elham اربابی , Fatemeh رستمی , Mitra ایمان , Parvane محمدی , Elham حمزه ای , Mohsen واحدی , Reza محبی , Mohamad وفایی , Reza فاطمی
Abstract:   (15313 Views)
  Introduction: Some studies have determined that polymorphism in insulin gene are associated with increased insulin level and resistant to insulin and also cause to increase risk of colorectal cancer (CRC). The goal of this study was to evaluate incidence of the insulin gene polymorphism (rs689) in an Iranian population and to investigate the role of this polymorphism in increased risk of CRC.   Materials and Methods: Genotyping of the insulin gene were determined in a series of 110 colorectal cancer patients and 110 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP).   Results: P value for genotype AT compared with AA, was 0.052 (OR=1.88, CI=0.99-3.5) and TT versus AA was 0.57 (OR=1.33 CI=0.48- 3.6). The results showed that the insulin gene polymorphism (rs689) is not a predisposing factor to increased risk to CRC (P=0.14). Incidence of mutant allele between patients and controls had no significant differences (OR=1.53 95% CI=0.98- 2.39, Pe=0.057).   Conclusion: These findings suggest that the insulin gene polymorphism (rs689) is not associated with increased risk of CRC.
Keywords: Polymorphism, Colorectal neoplasms, Insulin resistance, rs 689
Full-Text [PDF 151 kb]   (2414 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/01/8 | Accepted: 2011/08/28 | Published: 2012/01/15
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ارکانی M, صفائی A, کریمی K, اربابی E, رستمی F, ایمان M, et al . Association of the insulin gene polymorphism and colorectal cancer. Koomesh 1390; 13 (2) :172-176
URL: http://koomeshjournal.semums.ac.ir/article-1-1155-en.html


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Volume 13, Issue 2 ((پياپي 42)، زمستان 1390) Back to browse issues page
کومش Koomesh
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